Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen-Binding Protein and an Estrogen Response Element-Binding Protein
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منابع مشابه
Dominant-Negative Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen Binding Protein (Heat shock protein 27; Hsp27) and an Estrogen Response Element Binding Protein (hnRNPC-like Protein)
Coordinate, Dominant-Negative Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen Binding Protein (Heat shock protein 27; Hsp27) and an Estrogen Response Element Binding Protein (hnRNPC-like Protein) John S. Adams1, Hong S. Chen2, Martin S. Hewison2 1Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Burns and Allen Research Institute, Ce...
متن کاملInvolvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators.
Estrogen receptor (ER) and cAMP signaling pathways interact in a number of estrogen target tissues including mammary and uterine tissues. One aspect of this interaction is that estradiol and protein kinase A (PKA) activators can cooperate synergistically to activate ER-mediated transcription of both endogenous genes and reporter genes containing only estrogen response elements. The purpose of t...
متن کاملThe high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element.
We have examined the ability of the high-mobility group protein 1 (HMG1) to alter binding of the estrogen receptor DNA-binding domain (DBD) to the estrogen response element (ERE). HMG1 dramatically enhanced binding of purified, bacterially expressed DBD to the consensus vitellogenin A2 ERE in a dose-dependent manner. The ability of HMG1 to stabilize the DBD-ERE complex resulted in part from a d...
متن کاملVitamin D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element.
New World primates (NWP) exhibit a form of compensated resistance to vitamin D and other steroid hormones, including 17beta-estradiol. One postulated cause of resistance is that NWP cells overexpress one or more proteins which block hormone action by competing with hormone for its cognate hormone response element. Here we report that both nuclear and postnuclear extracts from NWP, but not Old W...
متن کاملAn Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein.
New World primates (NWPs) exhibit a compensated form of resistance to gonadal steroid hormones. We demonstrated recently that estrogen resistance in NWP cells was associated with the overexpression of two proteins, a nonreceptor-related, dominant-negative-acting estrogen response element (ERE)-binding protein (ERE-BP) and an intracellular estradiol-binding protein (IEBP). Based on the N-termina...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2008
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2007-0297